{"id":35049,"date":"2026-11-10T18:57:49","date_gmt":"2026-11-10T23:57:49","guid":{"rendered":"https:\/\/www.americanonewspaper.com\/es\/?p=35049"},"modified":"2026-11-10T19:55:31","modified_gmt":"2026-11-11T00:55:31","slug":"descubren-una-senal-molecular-que-anticipa-el-cancer-de-ovario","status":"publish","type":"post","link":"https:\/\/www.americanonewspaper.com\/es\/bacterias\/salud-bacterias\/descubren-una-senal-molecular-que-anticipa-el-cancer-de-ovario\/","title":{"rendered":"Descubren una se\u00f1al molecular que anticipa el c\u00e1ncer de ovario"},"content":{"rendered":"\n

Redacci\u00f3n ciencia, (EFE).<\/p>\n\n\n\n

El c\u00e1ncer de ovario suele diagnosticarse cuando la enfermedad ya se ha extendido pero, ahora, un equipo de cient\u00edficos ha descubierto una se\u00f1al molecular en la sangre que detecta el carcinoma intraepitelial tub\u00e1rico seroso, una etapa previa a la formaci\u00f3n del c\u00e1ncer de ovario seroso de alto grado.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Los detalles del estudio, realizado durante ocho a\u00f1os por un equipo internacional multiinstitucional, liderado por investigadores del Hoag Family Cancer Institute, de California (Estados Unidos), se han publicado este martes en la revista Nature Medicine<\/em>.<\/p>\n\n\n\n

El carcinoma intraepitelial tub\u00e1rico seroso o STIC es un grupo de c\u00e9lulas anormales microsc\u00f3picas que se forman en las trompas de Falopio y que no se ven en las pruebas de imagen y ni en los an\u00e1lisis de sangre utilizados para detectar c\u00e1ncer, por eso, el c\u00e1ncer de ovario suele descubrirse en etapas avanzadas. <\/p>\n\n\n\n

\"ABOGADOS<\/a>
ABOGADOS DE ACCIDENTES<\/figcaption><\/figure>\n\n\n\n

El estudio ha descubierto que las mujeres con STIC y c\u00e1ncer de ovario en fase temprana tienen niveles elevados de Tu-Stroma, una mol\u00e9cula de ARN asociada al microambiente tumoral, es decir, al proceso biol\u00f3gico que prepara el terreno al c\u00e1ncer debilitando a las c\u00e9lulas sanas para hacer espacio para las c\u00e9lulas tumorales. <\/p>\n\n\n\n

Los autores creen que encontrar una se\u00f1al de alerta como esta puede revelar el desarrollo del c\u00e1ncer a\u00f1os antes de que las pruebas convencionales lo detecten.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

\u201cEl c\u00e1ncer de ovario no comienza el d\u00eda que descubrimos un tumor. A menudo comienza mucho antes, con cambios microsc\u00f3picos en las trompas de Falopio que no podemos ver durante las revisiones rutinarias\u201d, explica Rajan Gogna, director de Investigaci\u00f3n Traslacional del Instituto Oncol\u00f3gico de Hoag. <\/p>\n\n\n\n

\u201cDurante d\u00e9cadas, nos hemos centrado en encontrar tumores peque\u00f1os. Luego nos planteamos una pregunta fundamentalmente diferente: \u00bfQu\u00e9 pasar\u00eda si pudi\u00e9ramos identificar las primeras se\u00f1ales de alerta moleculares antes incluso de que se desarrolle un c\u00e1ncer invasivo?\u201d.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Una prueba con notable precisi\u00f3n <\/strong><\/h2>\n\n\n\n

El estudio, probado en una muestra de mujeres, detect\u00f3 la condici\u00f3n precancerosa (STIC) en el 92,3 % de las mujeres que la ten\u00edan e identific\u00f3 correctamente al 98,2 % de las mujeres sanas. <\/p>\n\n\n\n

Y en simulaciones aplicadas a grupos de alto riesgo, el equipo descubri\u00f3 que aproximadamente el 72 % de los resultados positivos ser\u00edan precisos, mientras que un resultado negativo mostr\u00f3 una fiabilidad de casi el 100 %.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Tras este an\u00e1lisis, los investigadores analizaron muestras de sangre recogidas previamente de mujeres con diagn\u00f3sticos confirmados y con predisposici\u00f3n gen\u00e9tica, estableciendo un nuevo y prometedor enfoque para detectar el c\u00e1ncer de ovario en sus etapas biol\u00f3gicas m\u00e1s tempranas.<\/p>\n\n\n\n

A partir de ahora, los investigadores de Hoag planean realizar estudios cl\u00ednicos prospectivos con mujeres con y sin un riesgo gen\u00e9tico elevado de c\u00e1ncer de ovario. <\/p>\n\n\n\n

Para ello, recolectar\u00e1n muestras de sangre y realizar\u00e1n un seguimiento de las participantes a lo largo del tiempo para determinar con cuanta anticipaci\u00f3n se puede detectar esta se\u00f1al molecular, con qu\u00e9 fiabilidad identifica a las mujeres con el inicio de esta enfermedad y si, en \u00faltima instancia, puede ayudar a orientar las decisiones cl\u00ednicas.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

El objetivo a largo plazo es traducir este descubrimiento en un an\u00e1lisis de sangre cl\u00ednicamente validado que podr\u00eda transformar la vigilancia y la prevenci\u00f3n del c\u00e1ncer de ovario.<\/p>\n\n\n\n

Mujeres con antecedentes <\/strong><\/h2>\n\n\n\n

El impacto potencial de esta investigaci\u00f3n es especialmente significativo para las mujeres con un riesgo gen\u00e9tico elevado, incluidas aquellas con mutaciones en los genes BRCA1 o BRCA2. <\/p>\n\n\n\n

Actualmente muchas mujeres se someten a cirug\u00edas preventivas para extirpar sus trompas de Falopio y ovarios, a veces antes de completar poder tener hijos y a costa de una menopausia precoz. <\/p>\n\n\n\n

Pero si los pr\u00f3ximos estudios validan la prueba de sangre Tu-Stroma para uso cl\u00ednico, esto podr\u00eda proporcionar a las mujeres y a sus m\u00e9dicos, independientemente de si existe o no un riesgo conocido de c\u00e1ncer de ovario, una herramienta importante para fundamentar las decisiones cl\u00ednicas para la prevenci\u00f3n del c\u00e1ncer de ovario.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

\u201cPara las mujeres con alto riesgo, esto podr\u00eda transformar nuestra manera de abordar la prevenci\u00f3n\u201d, subraya Esha Madan, investigadora principal y jefa del grupo en el Laboratorio de Microambiente Tumoral de Hoag. <\/p>\n\n\n\n

\u201cActualmente, las decisiones sobre cirug\u00eda preventiva se basan principalmente en el riesgo hereditario, sin saber si existen lesiones precancerosas. Nuestro descubrimiento podr\u00eda proporcionar la informaci\u00f3n biol\u00f3gica que falta”, concluye.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"

Redacci\u00f3n ciencia, (EFE). El c\u00e1ncer de ovario suele diagnosticarse cuando la enfermedad ya se ha extendido pero, ahora, un equipo de cient\u00edficos ha descubierto una se\u00f1al molecular en la sangre que detecta el carcinoma intraepitelial tub\u00e1rico seroso, una etapa previa a la formaci\u00f3n del c\u00e1ncer de ovario seroso de alto grado. Los detalles del estudio, […]<\/p>\n","protected":false},"author":14,"featured_media":35050,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_acf_changed":false,"tdm_status":"","tdm_grid_status":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1854],"tags":[],"class_list":["post-35049","post","type-post","status-publish","format-standard","has-post-thumbnail","category-salud-bacterias"],"acf":[],"yoast_head":"\nDescubren una se\u00f1al molecular que anticipa el c\u00e1ncer de ovario - 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