{"id":29204,"date":"2025-10-07T13:45:03","date_gmt":"2025-10-07T17:45:03","guid":{"rendered":"https:\/\/www.americanonewspaper.com\/es\/?p=29204"},"modified":"2025-10-08T10:35:12","modified_gmt":"2025-10-08T14:35:12","slug":"cientificos-revierten-el-alzheimer-en-ratones-mediante-nanoparticulas","status":"publish","type":"post","link":"https:\/\/www.americanonewspaper.com\/es\/alzheimer\/cientificos-revierten-el-alzheimer-en-ratones-mediante-nanoparticulas\/","title":{"rendered":"Cient\u00edficos revierten el alzh\u00e9imer en ratones mediante nanopart\u00edculas"},"content":{"rendered":"\n

Barcelona (Espa\u00f1a), (EFE).<\/p>\n\n\n\n

Las nanopart\u00edculas, si se emplean en restaurar la funci\u00f3n adecuada de la barrera hematoencef\u00e1lica (BBB), el “guardi\u00e1n vascular” que regula el entorno del cerebro, pueden conseguir revertir el alzh\u00e9imer en modelos animales como ratones.<\/p>\n\n\n\n

As\u00ed, este avance, publicado en la revista Signal Transduction and Targeted Therapy, se centra en restaurar la funci\u00f3n normal del sistema vascular cerebral, en lugar de actuar directamente sobre las neuronas, como se hacia hasta ahora con las nanopart\u00edculas.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

La investigaci\u00f3n la han liderado conjuntamente el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC), en Espa\u00f1a, y el Hospital West China de la Universidad de Sichuan (WCHSU), y tambi\u00e9n han colaborado cient\u00edficos del Reino Unido. <\/p>\n\n\n\n

El art\u00edculo apunta que, a diferencia de la nanomedicina tradicional, que emplea nanopart\u00edculas como portadoras de mol\u00e9culas terap\u00e9uticas, este nuevo enfoque utiliza “f\u00e1rmacos supramoleculares” que son bioactivos por s\u00ed mismos. <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Estas nanopart\u00edculas no se dirigen a las neuronas, sino que restauran la funci\u00f3n adecuada de la barrera hematoencef\u00e1lica (BBB), el “guardi\u00e1n vascular” que regula el entorno del cerebro. Y al reparar esta interfaz cr\u00edtica, los investigadores consiguieron revertir la patolog\u00eda del Alzheimer en modelos animales, han explicado.<\/p>\n\n\n\n

El cerebro, recuerdan, es un \u00f3rgano que consume una gran cantidad de energ\u00eda, depende de un vasto suministro de sangre. <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

En ese sentido, precisamente, los hallazgos del estudio resaltan el papel crucial de la salud vascular en enfermedades como la demencia y el alzh\u00e9imer, que est\u00e1n relacionadas con un sistema vascular comprometido.<\/p>\n\n\n\n

Un interruptor para restablecer la eliminaci\u00f3n de toxinas <\/strong><\/h2>\n\n\n\n

En la enfermedad de Alzheimer, la acumulaci\u00f3n de la prote\u00edna amiloide-\u03b2 (A\u03b2) perjudica el funcionamiento normal de las neuronas y el equipo demostr\u00f3 que las nanopart\u00edculas supramoleculares act\u00faan como un interruptor que restablece el sistema de eliminaci\u00f3n de toxinas del cerebro. <\/h2>\n\n\n\n
\"\"<\/a><\/figure>\n\n\n\n

“Solo una hora despu\u00e9s de la inyecci\u00f3n observamos una reducci\u00f3n del 50-60 % en la cantidad de A\u03b2 dentro del cerebro”, destaca el primer coautor del estudio, Junyang Chen.<\/p>\n\n\n\n

Los efectos terap\u00e9uticos a largo plazo fueron a\u00fan m\u00e1s notables: en un experimento, un rat\u00f3n de 12 meses (equivalente a un humano de 60 a\u00f1os) tratado con las nanopart\u00edculas recuper\u00f3 el comportamiento de un rat\u00f3n sano despu\u00e9s de 6 meses, alcanzando una edad comparable a un humano de 90 a\u00f1os.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

El profesor de investigaci\u00f3n ICREA en el IBEC y l\u00edder del estudio, Giuseppe Battaglia, ha destacado asimismo que “el efecto a largo plazo proviene de la restauraci\u00f3n del sistema vascular del cerebro. Creemos que funciona como una cascada: cuando se acumulan especies t\u00f3xicas como la beta amiloide (A\u03b2), la enfermedad progresa”.<\/p>\n\n\n\n

Y a\u00f1ade: “Pero una vez que la vascularizaci\u00f3n puede funcionar nuevamente, empieza a eliminar A\u03b2 y otras mol\u00e9culas da\u00f1inas, lo que permite que todo el sistema recupere su equilibrio”.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

La tambi\u00e9n investigadora del grupo de Bi\u00f3nica Molecular del IBEC Lorena Ruiz P\u00e9rez ha explicado que el estudio “demostr\u00f3 una notable eficacia para lograr una r\u00e1pida eliminaci\u00f3n de A\u03b2, restaurar la funci\u00f3n saludable en la barrera hematoencef\u00e1lica y conducir a una sorprendente reversi\u00f3n de la patolog\u00eda del Alzheimer”.<\/p>\n\n\n\n

Los autores han coincidido en apuntar que el estudio es una v\u00eda “prometedora” para el desarrollo de intervenciones cl\u00ednicas efectivas, abordando las contribuciones vasculares a la enfermedad de Alzheimer y mejorando los resultados de los pacientes.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n
\"\"<\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"

Barcelona (Espa\u00f1a), (EFE). Las nanopart\u00edculas, si se emplean en restaurar la funci\u00f3n adecuada de la barrera hematoencef\u00e1lica (BBB), el “guardi\u00e1n vascular” que regula el entorno del cerebro, pueden conseguir revertir el alzh\u00e9imer en modelos animales como ratones. As\u00ed, este avance, publicado en la revista Signal Transduction and Targeted Therapy, se centra en restaurar la funci\u00f3n 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