{"id":21717,"date":"2024-03-21T14:15:12","date_gmt":"2024-03-21T18:15:12","guid":{"rendered":"https:\/\/www.americanonewspaper.com\/es\/?p=21717"},"modified":"2024-03-21T14:15:15","modified_gmt":"2024-03-21T18:15:15","slug":"la-proteina-pappa-por-sirtuinas","status":"publish","type":"post","link":"https:\/\/www.americanonewspaper.com\/es\/salud\/la-proteina-pappa-por-sirtuinas\/","title":{"rendered":"La Prote\u00edna PAPPA por Sirtuinas"},"content":{"rendered":"\n

Pek\u00edn, 21 mar (EFE).- <\/p>\n\n\n\n

Un equipo de cient\u00edficos chinos revel\u00f3 en un estudio reciente que los niveles elevados de prote\u00edna PAPPA, observados en el plasma de mujeres embarazadas y personas mayores, son impulsados por las sirtuinas, una familia de prote\u00ednas se\u00f1alizadoras clave en la regulaci\u00f3n del metabolismo.<\/p>\n\n\n\n

El estudio, llevado a cabo por cient\u00edficos del Instituto de Zoolog\u00eda y el Instituto de Gen\u00f3mica de Pek\u00edn, organizaciones dependientes de la Academia China de Ciencias, arroja m\u00e1s luz sobre el papel de la PAPPA (Prote\u00edna A Plasm\u00e1tica Asociada al Embarazo, por sus siglas en ingl\u00e9s) en el envejecimiento, el cual ya hab\u00eda sido sugerido por investigaciones previas.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Los expertos, cuyos hallazgos fueron publicados en la revista cient\u00edfica Development Cell, sugieren que las sirtuinas podr\u00edan estar detr\u00e1s del proceso de envejecimiento en diversos tipos de c\u00e9lulas humanas y proporciona una mejor comprensi\u00f3n sobre el proceso de envejecimiento, lo que podr\u00eda servir para hallar nuevas formas de aminorarlo.<\/p>\n\n\n\n

La prote\u00edna PAPPA, identificada inicialmente en altas concentraciones en el plasma de mujeres embarazadas, ha sido objeto de estudio durante d\u00e9cadas, sin que los expertos hayan llegado a conclusiones acerca de su funci\u00f3n espec\u00edfica en el cuerpo humano.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

En el estudio, se observ\u00f3 que los niveles de PAPPA eran significativamente m\u00e1s elevados en el plasma de los ancianos que en el de los j\u00f3venes, lo que sugiere su posible papel como biomarcador del envejecimiento humano.<\/p>\n\n\n\n

Los investigadores, utilizando t\u00e9cnicas avanzadas de edici\u00f3n gen\u00f3mica para estudiar las c\u00e9lulas madre humanas, observaron que la eliminaci\u00f3n de cualquier sirtuina aumentaba la interacci\u00f3n entre ciertas regiones del genoma, lo que a su vez induc\u00eda la expresi\u00f3n de genes asociados con el envejecimiento: en particular, la prote\u00edna PAPPA se expresaba de manera an\u00f3mala en ausencia de las sirtuinas.<\/p>\n\n\n\n

Descubrieron que la ausencia de cualquiera de los miembros de la familia de las sirtuinas acelera el envejecimiento de las c\u00e9lulas mesenquimales, un tipo de c\u00e9lula madre.<\/p>\n\n\n\n

Las sirtuinas han sido objeto de inter\u00e9s en investigaciones previas sobre si la restricci\u00f3n cal\u00f3rica podr\u00eda ralentizar el proceso de envejecimiento, si bien la Academia China de Ciencias asegur\u00f3 que se han realizado pocas investigaciones sobre las funciones biol\u00f3gicas de PAPPA y las sirtuinas y la interacci\u00f3n entre ellas.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"

Pek\u00edn, 21 mar (EFE).- Un equipo de cient\u00edficos chinos revel\u00f3 en un estudio reciente que los niveles elevados de prote\u00edna PAPPA, observados en el plasma de mujeres embarazadas y personas mayores, son impulsados por las sirtuinas, una familia de prote\u00ednas se\u00f1alizadoras clave en la regulaci\u00f3n del metabolismo. El estudio, llevado a cabo por cient\u00edficos del […]<\/p>\n","protected":false},"author":7,"featured_media":21718,"comment_status":"closed","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"categories":[577,592],"tags":[],"class_list":{"0":"post-21717","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-naturaleza","8":"category-salud"},"acf":[],"yoast_head":"\nLa Prote\u00edna PAPPA por Sirtuinas - Americano Newspaper<\/title>\n<meta name=\"description\" content=\"Un equipo de cient\u00edficos chinos revel\u00f3 en un estudio reciente que los niveles elevados de prote\u00edna PAPPA, observados en el plasma de mujeres embarazadas y personas mayores, son impulsados por las sirtuinas, una familia de prote\u00ednas se\u00f1alizadoras clave en la regulaci\u00f3n del metabolismo.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.americanonewspaper.com\/es\/salud\/la-proteina-pappa-por-sirtuinas\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La Prote\u00edna PAPPA por Sirtuinas\" \/>\n<meta property=\"og:description\" content=\"Un equipo de cient\u00edficos chinos revel\u00f3 en un estudio reciente que los niveles elevados de prote\u00edna PAPPA, observados en el plasma de mujeres embarazadas y personas mayores, son impulsados por las sirtuinas, una familia de prote\u00ednas se\u00f1alizadoras clave en la regulaci\u00f3n del metabolismo.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.americanonewspaper.com\/es\/salud\/la-proteina-pappa-por-sirtuinas\/\" \/>\n<meta property=\"og:site_name\" content=\"Americano Newspaper\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/AmericanoNewspaper\/\" \/>\n<meta property=\"article:published_time\" content=\"2024-03-21T18:15:12+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-21T18:15:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.americanonewspaper.com\/es\/wp-content\/uploads\/2024\/03\/China-ancianos.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Author\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Author\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.americanonewspaper.com\\\/es\\\/salud\\\/la-proteina-pappa-por-sirtuinas\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.americanonewspaper.com\\\/es\\\/salud\\\/la-proteina-pappa-por-sirtuinas\\\/\"},\"author\":{\"name\":\"Author\",\"@id\":\"https:\\\/\\\/www.americanonewspaper.com\\\/es\\\/#\\\/schema\\\/person\\\/8967f6b8af7e37bcbbe61f68580ff088\"},\"headline\":\"La Prote\u00edna PAPPA por Sirtuinas\",\"datePublished\":\"2024-03-21T18:15:12+00:00\",\"dateModified\":\"2024-03-21T18:15:15+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.americanonewspaper.com\\\/es\\\/salud\\\/la-proteina-pappa-por-sirtuinas\\\/\"},\"wordCount\":414,\"publisher\":{\"@id\":\"https:\\\/\\\/www.americanonewspaper.com\\\/es\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.americanonewspaper.com\\\/es\\\/salud\\\/la-proteina-pappa-por-sirtuinas\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.americanonewspaper.com\\\/es\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/China-ancianos.jpg\",\"articleSection\":[\"Naturaleza\",\"Salud\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.americanonewspaper.com\\\/es\\\/salud\\\/la-proteina-pappa-por-sirtuinas\\\/\",\"url\":\"https:\\\/\\\/www.americanonewspaper.com\\\/es\\\/salud\\\/la-proteina-pappa-por-sirtuinas\\\/\",\"name\":\"La Prote\u00edna PAPPA por Sirtuinas - 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