{"id":21584,"date":"2024-03-05T17:20:32","date_gmt":"2024-03-05T22:20:32","guid":{"rendered":"https:\/\/www.americanonewspaper.com\/es\/?p=21584"},"modified":"2024-03-05T17:20:35","modified_gmt":"2024-03-05T22:20:35","slug":"identifican-una-nueva-diana-terapeutica-contra-el-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.americanonewspaper.com\/es\/cancer-de-mama\/identifican-una-nueva-diana-terapeutica-contra-el-cancer-de-mama\/","title":{"rendered":"Identifican una nueva diana terap\u00e9utica contra el c\u00e1ncer de mama."},"content":{"rendered":"\n

Madrid, (EFE). <\/p>\n\n\n\n

Un equipo internacional de investigadores, entre los que se encuentra el espa\u00f1ol Juan Cadi\u00f1anos, descubri\u00f3 una nueva diana terap\u00e9utica contra el c\u00e1ncer de mama que abre nuevas posibilidades de tratamiento.<\/p>\n\n\n\n

El hallazgo, que recoge este martes la revista de la Asociaci\u00f3n Americana para el Avance de la Ciencia (AAAS, por sus siglas en ingl\u00e9s), describe el papel fundamental que desempe\u00f1a un conjunto de prote\u00ednas a la hora de frenar la multiplicaci\u00f3n de las c\u00e9lulas tumorales en determinados tipos de c\u00e1ncer de mama.<\/p>\n\n\n\n

Los investigadores ya hab\u00edan desvelado previamente que hay una serie de tumores de mama que presentan niveles altos de una prote\u00edna denominada Aurora A, implicada en la divisi\u00f3n celular y, por tanto, en la multiplicaci\u00f3n del c\u00e1ncer, explica a EFE Cadi\u00f1anos, director cient\u00edfico de la Fundaci\u00f3n Centro M\u00e9dico de Asturias.<\/p>\n\n\n

\n
\"\"<\/a><\/figure>\n<\/div>\n\n\n

La paradoja es que aunque se hab\u00edan dise\u00f1ado f\u00e1rmacos para inhibir la prote\u00edna Aurora A e impedir la evoluci\u00f3n de los tumores, los resultados de los ensayos cl\u00ednicos “no hab\u00edan sido muy positivos”.<\/p>\n\n\n\n

La novedad de esta investigaci\u00f3n es el descubrimiento de una agrupaci\u00f3n de varias prote\u00ednas formadas por supresores tumorales, que disminuyen los niveles de Aurora A, y la capacidad de reproducci\u00f3n del c\u00e1ncer.<\/p>\n\n\n\n

En ese complejo proteico, los cient\u00edficos identificaron una prote\u00edna en concreto, llamada PTEN, que es un potente supresor tumoral.<\/p>\n\n\n\n

Un freno al c\u00e1ncer<\/strong><\/h2>\n\n\n\n

\u201cHemos hallado un freno al c\u00e1ncer de mama\u201d, subray\u00f3 el cient\u00edfico espa\u00f1ol.<\/p>\n\n\n\n

El equipo de Cadi\u00f1anos ya comprob\u00f3 en experimentos con ratones modificados gen\u00e9ticamente que si perd\u00edan la prote\u00edna PTEN aparec\u00edan tumores de mama y niveles elevados de Aurora A, en un hallazgo que recogi\u00f3 la revista Nature Genetics en 2017.<\/p>\n\n\n\n

Otros autores del presente estudio, como Subatra Sen y Hirosi Katayama (investigadores del centro MD Anderson de Texas), hab\u00edan visto los mismos resultados con muestras celulares humanas cultivadas en laboratorio: a menor niveles de PTEN m\u00e1s posibilidades de descontrol de la prote\u00edna Aurora A y del desarrollo de los tumores de mama asociados a su sobreexpresi\u00f3n.<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

Ahora, tras comprobar el potencial conjunto de PTEN y otras prote\u00ednas, los investigadores demostraron, en ensayos con ratones, que la combinaci\u00f3n de dos f\u00e1rmacos: Alisertib, para inhibir la actividad de Aurora A, y Fimepinostat, para favorecer su degradaci\u00f3n, da muy buenos resultados para suprimir el crecimiento de los tumores de mama.<\/p>\n\n\n\n

Mientras ambos f\u00e1rmacos no son de gran eficacia por separado, la combinaci\u00f3n de ambos se demostr\u00f3 exitosa en ensayos precl\u00ednicos.<\/p>\n\n\n\n

\u201cSiempre se van a requerir ensayos adicionales, pero esta combinaci\u00f3n de f\u00e1rmacos abre nuevas posibilidades de tratamiento y estrategias terape\u00faticas en los c\u00e1nceres de mama con sobreexpresi\u00f3n de Aurora A\u201d, asever\u00f3 Cadi\u00f1anos.<\/p>\n","protected":false},"excerpt":{"rendered":"

Madrid, (EFE). Un equipo internacional de investigadores, entre los que se encuentra el espa\u00f1ol Juan Cadi\u00f1anos, descubri\u00f3 una nueva diana terap\u00e9utica contra el c\u00e1ncer de mama que abre nuevas posibilidades de tratamiento. El hallazgo, que recoge este martes la revista de la Asociaci\u00f3n Americana para el Avance de la Ciencia (AAAS, por sus siglas en […]<\/p>\n","protected":false},"author":13,"featured_media":21585,"comment_status":"closed","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_acf_changed":false,"tdm_status":"","tdm_grid_status":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"categories":[591,593,594,592],"tags":[],"class_list":{"0":"post-21584","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cancer-de-mama","8":"category-ciencia-y-tecnologia","9":"category-investigacion-medica","10":"category-salud"},"acf":[],"yoast_head":"\nIdentifican una nueva diana terap\u00e9utica contra el c\u00e1ncer de mama. - 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